Detail of Dr. Kelvin Leung
Research Programmes of Dr. Kelvin LEUNG

Emerging contaminants in the environment

Emerging contaminants are defined as compounds that are not currently covered by existing water-quality regulations, but thought to be potential threats to environmental ecosystems, human health and safety. We are interested in developing analytical methods for identifying these emerging contaminants, probing for their environmental fate, transformation mechanisms and environmental implications in ecosystem.

Elemental Bioimaging

Elemental bioimaging is one of the most notable applications of the hyphenated technologies – laser ablation-inductively coupled plasma mass spectrometry (LA-ICP-MS). While standalone MS or atomic spectroscopy techniques perform typical analyses in bulk samples, the couple of LA-ICP-MS is functional in surface scanning and depth profiling to obtained high resolution distribution maps of multiple elements in samples. More advanced applications such as bio-molecular mapping is enabled by making use of element tags to label specific proteins, metabolites, cells in tissue sections; this is important towards the understanding of the biochemistry and interaction of enzymes and (metallo)proteins. LA-ICP-MS is currently an important workhorse for our extensive work on toxicology, pharmacology and pathophysiology research. 

The Development of Mass Spectrometric Methods for Clinical Laboratory Diagnosis

Our research group is actively engaged in the development of new analytical techniques for clinical and bioanalytical applications. In collaboration with Queen Mary Hospital, we are continuously exploring new avenues for facile diagnosis of diseases in clinical laboratory.
Examples of new diagnostic methods include the development of rapid sample extraction and sensitive LC-MS/MS analyses for screening puffer fish tetrodotoxin poisoning and the diagnosis of Cushing syndrome. We are also interested in longer term establishment in clinical research such as uncovering local reference intervals, exposure markers, molecular patterns for the inborn errors of metabolism diagnosis. 

Related Publications:

99.     A. J. Li, Z. Sang, C.-H. Chow, J. C.-F. Law, Y. Guo, K. S.-Y. Leung*, Environmental behavior of 12 UV filters and photocatalytic profile of ethyl-4-aminobenzoate, Journal of Hazardous Materials, 2017, 337, 115-125
98.    A. J. Li, P. Wu, J. C.-F. Law, C.-H. Chow, C. Postigo, Y. Guo, K. S.-Y. Leung*, Transformation of acesulfame in chlorination: Kinetics study, identification of byproducts, and toxicity assessment, Water Research, 2017, 117, 157-166
97.    L.L. Jia, X.Y. Lou, Y. Guo, K. S.-Y. Leung*, E. Y. Zeng, Occurrence of phthalate esters in over-the-counter medicines from China and its implications for human exposure, Environment International, 2017, 98, 137–142
96.    K.L. Ho, K.K. Yuen, M.S. Yau, M. B. Murphy, Y. Wan, B. M.-W. Fong, S. Tam, J. P. Giesy, K. S.-Y. Leung, M. H.-W. Lam, Glucuronide and sulfate conjugates of tetrabromobisphenol A (TBBPA): Chemical synthesis and correlation between their urinary levels and plasma TBBPA content in voluntary human donors, Environment International, 2017, 98, 46–53
95.    X. Wang, Z. Huang, P.C. Chu, Y. Cai, K. S.-Y. Leung, Judy T.-S. Lum, N.H. Cheung, The mechanism of ArF laser-induced fluorescence of dense plume matter, J. Anal. At. Spectrom., 2016, 31, 2363-2374  
94.    Y. Cai, Z. Huang, M. H.C. Cheung, V. Motto-Ros, P.-C. Chu, Y. Wang, H. Zhong, R. Yuen, K. S.-Y. Leung, J. T.-S. Lum, S.-K. Ho and N.-H. Cheung, Elemental Analysis of Chinese Black Inks on Xuan Paper by ArF Laser-Excited Plume Fluorescence, Analytical Chemistry, 2016, 88, 10971-10978
93.     P.Y.K. Yue, X.Y. Yang, J.J. Xiao, K. S.-Y. Leung, T.S. Lum, J. Li, X.G. Zhang, G.H. Lu, Determination of heavy metal elements in Chuanmingshen violaceum by ICP-MS, Chinese Traditional and Herbal Drugs, 2016, 47, 9, 1595-1600
92.     T. -S. Lum, C. -L. Ho, Y. -K. Tsoi, C. -H. Siu, P. Y. K. Yue, W. -Y. Wong, K. S. -Y. Leung*, Elemental bioimaging of platinum in mouse tissues by laser ablation-inductively coupled plasma-mass spectrometry for the study of localization behavior of structurally similar complexes, Int J Mass Spectrom., 2016, 404, 40-47
91.     Z. -Y. Sang, K. S. -Y. Leung*, Environmental occurrence and ecological risk assessment of organic UV filters in marine organisms from Hong Kong coastal waters, Sci Total Environ, 2016, 566-567,489-498
90.     Selvam, K. Kwok, Y. M. Chen, A. Cheung, K. S. -Y. Leung*, J. W.C. Wong, Influence of Livestock Activities on Residue Antibiotic levels of Rivers in Hong Kong, Environ Sci Pollut R., 2016, 24(10), 9058-9066
89.     T. -S. Lum, Y. K. Tsoi, P. Y. K. Yue, K. S. -Y. Leung*, Therapeutic Drug Monitoring Using LA-ICP-MS: Initial Studies with Metallodrugs in Mouse Whiskers, Microchem. J., 2016, in 127, 94-101
88.     T. -S. Lum, K. S. -Y. Leung*, Strategies to overcome spectral interference in ICP-MS detection, J. Anal. Atom. Spectrom., 2016, 31, 1078-1088 (Invited as front cover)
87.     J. Li, O. J. Schmitz, S. Stephan, C. Lenzen, P. Y. K. Yue, K.B. Li, H.S. Li, K. S. -Y. Leung*, Photocatalytic transformation of acesulfame: transformation products identification and embryotoxicity study, Water Res., 2016, 89, 68-75
86.     P. Y. K. Yue, H. M. Leung, A. J. Li, T. N. C. Chan, T. S. Lum, Y. L. Chung, Y. H. Sung, M. H. Wong, K. S. -Y. Leung, E.Y. Zeng, Angiosuppressive properties of marine-derived compounds—a mini review, Environ Sci Pollut R., 2015, 1-12
85.     K.-L. Ho, M.-S. Yau, M. B. Murphy, Y. Wan, B. M.-W. Fong, S. Tam, J. P. Giesy, K. S.-Y. Leung, M. H.-W. Lam, Urinary bromophenol glucuronide and sulfate conjugates: Potential human exposure molecular markers for polybrominated diphenyl ethers, Chemosphere, 2015, 133, 6-12
84.     Z. Y. Sang, Y. N. Jiang, Y. -K. Tsoi, K. S. -Y. Leung*, Evaluating the environmental impact of artificial sweeteners: A study of their distributions, photodegradation and toxicities, Water Res., 2014, 52, 260-264
83.     T. -S. Lum, Y. -K. Tsoi, K. S. -Y. Leung*, Current developments in clinical sample preconcentration prior to elemental analysis by atomic spectrometry: a comprehensive literature review, J. Anal. Atom. Spectrom., 2014, 29(2), 234-241.
82.     K. S.-Y. Leung*, B. M. W. Fong, LC-MS/MS in the routine clinical laboratory – Has its time come? (Invited review), Anal Bioanal Chem, 2014, 406, 2289-2301
81.     T. T. Xiao, M. Xu, Yang. X.H, L. Kok, Y. L. Chow, Z. Z. Zhao, K. S.-Y. Leung, Z. J. Yang, X. Y. Tian, Z. Li, M. Y. Xin, W. Xu, The evaluation on embryotoxicity of Dipsaci Radix with mice and embryonic stem cells, J. Ethnopharmacol, 2014, 151(1), 114-122 
80.     Y. M. Ho, Y. -K. Tsoi, K. S. -Y. Leung*, Ionic-liquid-based dispersive liquid–liquid microextraction for high-throughput multiple food contaminant  screening, J. Sep. Sci., 2013, 36(23), 3791-3798. 
79.     P. Y. -K. Yue, Y. -Y. Wong, K. Y. -K. Wong, Y. -K. Tsoi, K. S. -Y. Leung*, Current evidence for the hepatoprotective activities of the medicinal mushroom Antrodia Cinnamonmea, Chin. Med., 2013, 8:21.
78.     P. C. Chu, B. Cai, Y. K. Tsoi, R. Yuen, K. S. -Y. Leung, N. H. Cheung, Forensic analysis of laser printed ink by x-ray fluorescence and laser-excited plume fluorescence, Anal Chem., 2013, 85(9), 4311-4315.
77.     Y. M. Ho, Y. K. Tsoi, K. S. -Y. Leung*, Highly sensitive and selective organophosphate screening in twelve commodities of fruits, vegetables and herbal medicines by dispersive liquid–liquid microextraction, Anal. Chim. Acta, 2013, 775, 58-66
76.     B.M.W. Fong, S. Tam, K. S. -Y. Leung*, Determination of plasma cholesterol sulfate by LC-APCI-MS/MS in the context of pediatric autism, Talanta, 2013, 116, 115-121
75.     S. Krieger, A. v. Trotha, K. S. -Y. Leung, O. J. Schmitz, Development, optimization and use of an APCI source with temperature-controlled vaporization of solid samples, Anal. Biol. Chem., 2013, 405(4), 1373-1381
74.     Z. Y. Sang, Y. T. Wang, Y. -K. Tsoi, K. S. -Y. Leung*, CODEX-compliant eleven organophosphorus pesticides screening in multiple commodities using headspace-solid phase microextraction-gas chromatography-mass spectrometry, Food Chem., 2013, 136(2), 710-717
73.     Y. M. Chen, K. S. -Y. Leung*, W. C. Wong, A. Selvam, Preliminary Occurrence Studies of Antibiotic Residues in Hong Kong and Pearl River Delta, Environ. Monit. Assess., 2013,185(1), 745-754
72.     C. H. Chui, K. W. Man, W. F. Tsang, P. L. Lam, K. S. -Y. Leung, W. Y. Wong, C. W. Kan, K. H. Lam, Study of cytotoxic effect for Fenton degradation of laboratory-scale synthetic dye-containing wastewater, Color. Technol., 2013, 129(6), 398-402
71.     Selvam, Z. Y. Zhao, Y. C. Li, Y. M. Chen, K. S. –Y. Leung, J. W. C. Wong, Degradation of tetracycline and sulfadiazine during continuous thermophilic composting of pig manure and sawdust, Environ. Technol., 2013, 34(16), 2433-2441
70.     K. L. Ho, M. B. Murphy, Y. Wan, B. M.-W. Fong, S. Tam, J. P. Giesy, K. S. –Y. Leung, M. H. -W. Lam, Synthesis and characterization of bromophenol glucuronide and sulfate conjugates for their direct LC-MS/MS quantification in human urine as potential exposure markers for polybrominated diphenyl ethers, Anal. Chem., 2012, 84 (22), 9881-9888
69.     K. K.W. Chung, S. P. L. Chen, S. W. Ng, T. W. L. Mak, K. S. -Y. Leung*, Measurement of Yunaconitine and Crassicauline A in small-volume blood serum samples by LC-MS/MS: Tracing of aconite poisoning in clinical diagnosis, Talanta, 2012, 97, 491-498
68.     B. M. W. Fong, S. Tam, K. S. -Y. Leung*, Quantification of acylglycines in human urine by HPLC electrospray ionization-tandem mass spectrometry and the establishment of pediatric reference interval in local Chinese, Talanta, 2012, 88, 193-200
67.     Y. K. Tsoi, Y. M. Ho, K. S. -Y. Leung*, Selective Recognition of Arsenic by Tailoring Ion-imprinted Polymer for ICP-MS Quantification, Talanta, 2012, 89,162-168
66.     Y. K. Chan, H. H. Kwok, L. S. Chan, R. N. S. Wong, N. K. Mak, K. S. -Y. Leung, J. Shi, P. Y. K. Yue, An indirubin derivative, E804, exhibits potent angiosuppressive activity, Biochem Pharmacol, 2012, 83(5), 598-607
65.     C. L. Ho, K. L. Wong, H. K. Kong, Y. M. Ho, C. T. L. Chan, W. M. Kwok, K. S. -Y. Leung, H. L. Tam, M. H. W. Lam, X.F. Ren, A. M. Ren, J. K. Feng, W. Y. Wong, A strong two-photon induced phosphorescent Golgi-specific in vitro marker based on a heteroleptic iridium complex, Chem. Commun., 2012, 48(19), 2525-2527
64.     P. Y. K. Yue, Y. Y. Wong, Tony, Y. K. Chan, C. K. M. Law, Y. K. Tsoi, K. S. -Y. Leung*, Review of biological and pharmacological activities of the endemic Taiwanese bitter medicinal mushroom, Antrodia camphorata (M. Zang et C. H. Su) Sh. H. Wu et al. (Higher Basidiomycetes), Int. J. Med. Mushrooms (Invited Review), 2012, 14, 241-256
63.     M. Xu, X. Y. Tian, K. S. -Y. Leung, K. C. Lee, T. C. Chow, B. Deng, C. M. Yiu, C. I. Chow, Z. Z. Zhao, Z. J. Yang,F. W. Fong, T. T. Xiao, W. Xu, P. X. Deng, Embryotoxicity of Psoralea corylifolia L.: In vivo and in vitro studies, Birth Defects Res. B, 2012, 95(6), 386-394
62.     Y. K. Tsoi, K. S. -Y. Leung*, Toward the use of immobilized activated carbon in speciations: Selective preconcentration of selenite and selenate in environmental waters, J. Chromatogr. A, 2011, 1218, 2160-2164.
61.     K. S. -Y. Leung*, B.M.W. Fong, Y. K. Tsoi, Analytical challenges: determination of Tetrodotoxin in human urine and plasma by LC-MS/MS, Mar. Drugs (Invited Review), 2011, 9(11), 2291-2303
60.     B. M. W. Fong, S. Tam, S. H. Tsui, K. S. -Y. Leung*, Development and validation of a high-throughput double solid phase extraction-liquid chromatography-tandem mass spectrometry method for the determination of tetrodotoxin in human urine and plasma, Talanta, 2011, 83, 1030-1036
59.     X. Y. Tian, M. Xu, B. Deng, K. S. -Y. Leung, K. F. Cheng, Z. Z. Zhao, S. P. Zhang, Z. J. Yang, P. X. Deng, D. Y. Xu, X. P. Xu, I. Koo, M. Wong, The effects of Boehmeria nivea (L.) Gaud. on embryonic development: In vivo and in vitro studies, J. Ethnopharmacol., 2011, 134, 393-398.
58.     Y. K. Tsoi, S. Tam, K. S. -Y. Leung*, Rapid speciation of methylated and ethylated mercury in urine using headspace Solid Phase Microextraction coupled to LC-ICP-MS, J. Anal. Atom. Spectrom, 2011, 25, 1758-1762.
57.     Y. K. Tsoi, K. S. -Y. Leung*, Simultaneous determination of seven elemental species in estuarine waters by LC-DRC-ICP-MS, J. Anal. Atom. Spectrom, 2010, 25, 880-885.
56.     B. M. W. Fong, S. Tam, K. S. -Y. Leung*, Improved liquid chromatography-tandem mass spectrometry method in clinical utility for the diagnosis of Cushing's syndrome, Anal. Bioanal. Chem., 2010, 396, 783-790.
55.     Y. L. Liu, X. Di, X. C. Liu, W. J. Shen, K. S. -Y. Leung*, Development of a LC-MS/MS method for the determination of antrodin B and antrodin C from Antrodia Camphorata extract in rat plasma for pharmacokinetic study, J. Pharm. Biomed. Anal., 2010, 53, 781-784.
54.     G. H. Lu, Z. Q. Dong, Q. Wang, G. S. Qian, W. H. Huang, Z. H. Jiang, K. S. -Y. Leung, Z. Z. Zhao, Toxicity assessment of nine types of decoction pieces from the daughter root of Aconitum carmichaeli (Fuzi) based on chemical analysis of diester diterpenoid Alkaloids, Planta Med., 2010, 76, 825-830.
53.     S. Zhao, K. S. -Y. Leung*, Quality evaluation of mycelial Antrodia Camphorata by using high-performance liquid chromatography coupled with diode array detector and mass spectrometry, Chin. Med., 2010, 5:4.
52.     G. Lv, S. Cheng, K. Chan, K. S. -Y. Leung, Z. Zhao, Determination of free ferulic acid and total ferulic acid in Chuanxiong by high-performance liquid chromatography for quality, China Journal of Chinese Materia Medica, 2010, 35, 194-198.
51.     C. H. Chui, R. S. -M. Wong, R. Gambari, G. Y. -M. Cheng, M. C. -W. Yuen, K. W. Chan, S. W. Tong, F. Y. Lau, B. S. Lai, K. H. Lam, C. L. Ho, C. W. Kan, K. S. -Y. Leung*, W. Y. Wong, Antitumor activity of diethynylfluorene derivatives of gold(I), Bioorg. Med. Chem., 2009,17, 7872-7877.
50.     D. Chen, S. Zhao, K. S. -Y. Leung*, Improved quality assessment of proprietary Chinese medicines based on multi-chemical class fingerprinting, J. Sep. Sci., 2009, 32, 2892-2902.
49.     X. Y. Tian, L. M. Cheung, K. S. -Y. Leung, Q. Chen, D. Bin, X. D. Ping, M. Xu, The effects of Scutellaria baicalensis on embryonic development, Birth Defects Res. B. Dev. Reprod. Toxicol., 2009, 86, 79-84.
48.     K. S. -Y. Leung*, C. M. Fu, Improved chromatographic assessment of chinese medicinal products by multi-chemical classes analysis, Planta Med., 2009, 75, 1171-1179.
47.     J. Meng, K. S. -Y. Leung, X. P. Dong, Y. S. Zhou, Z. H. Jiang, Z. Z. Zhao, Simultaneous quantification of eight bioactive components of Houttuynia cordata and related Saururaceae medicinal plants by on-line high performance liquid chromatography-diode array detector-electrospray mass spectrometry, Fitoterapia, 2009, 80, 468-474
46.     C. M. Fu, G. H. Lu, O. J. Schmitz, Z. W. Li, K. S. -Y. Leung*, Improved chromatographic fingerprints for facile differentiation of two Ganoderma spp., Biomed. Chromatogr., 2009, 23, 280-288.
45.     K. Chan, K. S. -Y. Leung*, S. Zhao, Harmonization of monographic standards is needed to ensure the quality of Chinese medicinal materials (Invited Review), 2009, Chin. Med., 4:18.
44.     G. S. Qian, S. Y. Leung, G. H. Lu, K. S. -Y. Leung*, Optimization and validation of a chromatographic method for the simultaneous quantification of six bioactive compounds in Rhizoma et Radix Polygoni Cuspidati, J. Pharm. Pharmacol., 2008, 60,107-113.
43.     G. H. Lu, Q Zhou, S. Q. Sun, K. S. -Y. Leung, H. Zhang, Z. Z. Zhao, Differentiation of Asian ginseng, American ginseng and Notoginseng by fourier transform infrared spectroscopy combined with two-dimensional correlation infrared spectroscopy, J. Mol. Struct., 2008, 883, 91-98.
42.     Z. Z. Zhao, Z. T. Liang, Z. H. Jiang, K. S. -Y. Leung, C. L. Chan, H. Y. Chan, J. Sin, T. O. Man, K. W. Law, Comparative study on the aristolochic acid I content of Herba Asari for safe use, Phytomedicine, 2008, 15, 741-748.
41.     G. H. Lu, S. Q. Cheung, K. S. -Y. Leung, J. Y. Ma, K. Chan, Z. Z. Zhao, Determination of free and total available ferulic acid in different types of Chinese Angelica by high performance liquid chromatography, J. Food Drug Anal., 2007, 15, 438-446.
40.     K. S. -Y. Leung*, K. Chan, A. Bensoussan, M. J. Munroe, Application of atmospheric pressure chemical ionisation mass spectrometry in the identification and differentiation of Panax Species, Phytochem. Anal., 2007, 18, 146-150.
39.     T. Yi, K. S. -Y. Leung* G. H. Lu, H. Zhang, K. Chan., Identification and determination of the major constituents in traditional Chinese medicinal plant Polygonum multiflorum Thunb by HPLC coupled with PAD and ESI-MS, Phytochem. Anal., 2007, 18, 181-187.
38.     T. Yi, K. S. -Y. Leung, G. H. Lu, H. Zhang, Comparative analysis of Ligusticum chuanxiong and related umbelliferous medicinal plants by high performance liquid chromatography-electrospray ionization mass spectrometry, Planta Med., 2007, 73, 392-398.
37.     J. L. Gao, K. S. -Y. Leung, Y. T. Wang, C. M. Lai, S. P. Li, L. F. Hu, G. H. Lu, Z. L. Yu, Qualitative and quantitative analyses of nucleosides and nucleobases in Ganoderma spp. by HPLC-DAD-MS, J. Pharm. Biomed. Anal., 2007, 44, 807-811.
36.     G. S. Qian, Q Wang, K. S. -Y. Leung, Y. Qin, Z. Z. Zhao, Z. H. Jiang, Quality assessment of Rhizoma et Radix Notopterygii by HPTLC and HPLC fingerprinting and HPLC quantitative analysis, J. Pharm. Biomed. Anal., 2007, 44, 812-817.
35.     J. Meng, X. P. Dong, Y. S. Zhou, Z. H. Jiang, K. S. -Y. Leung, Z. Z. Zhao, Orthogonal experiment using SFE-CO2 in extraction of essential oil from fresh Houttuynia cordata and analysis of essential oil by GC-MS, China Journal of Chinese Materia Medica, 2007, 32, 215-217.
34.     J. Meng, X. P. Dong, Y. S. Zhou, Z. H. Jiang, K. S. -Y. Leung, Z. Z. Zhao, Studies on chemical constituents of phenols in fresh Houttuynia cordata, China Journal of Chinese Materia Medica, 2007, 32, 929-931.
33.     T. Yi, K. S. -Y. Leung*, G. H. Lu, K. Chan, H. Zhang, Simultaneous Qualitative and Quantitative analyses of the major constituents in the rhizome of Ligusticum chuanxiong using HPLC-DAD-MS, Chem. Pharm. Bull., 2006, 54, 255-259.
32.     Z. T. Liang, Z. H. Jiang, K. S. -Y. Leung, Z. Z. Zhao, Determination of iridoid glucosides for quality assessment of Herba Oldenlandiae by high-performance liquid chromatography, Chem. Pharm. Bull., 2006, 54, 1131-1137.
31.     Z. Z Zhao, Y. N Hu, Z. T Liang, J. P. S Yuen, Z. H. Jiang, K. S. -Y. Leung,. Authentication is fundamental for standardization of Chinese medicines. Planta Med. 2006, 72, 1-10.
30.     Z. Z. Zhao, Z. T. Liang, Z. H. Jiang, K. S. -Y. Leung, C. L. Chan, Authentication and differentiation of two easily confusable Chinese materia medica: Herba Solani Lyrati and Herba Aristolochiae Mollissimae, J. Food Drug Anal., 2006, 1, 36-43.
29.     K. K. M. Yue, K. W. Lee, K. K. C. Chan, K. S. -Y. Leung, A. W. N. Leung, C. H. K. Cheng, Danshen prevents the occurrence of oxidative stress in the eye and aorta of diabetic rats without affecting the hyperglycemic state, J. Ethnopharmacol., 2006, 106, 136-141.
28.     Y. Wu, A. Y. -T. Ho, P. Y. Qian, K. S. -Y. Leung, Z. W. Cai, J. M. Lin, Determination of paralytic shellfish toxins in Dinoflagellate Alexandrium tamarense by using isotachophoresis/capillary electrophoresis, J. Sep. Sci., 2006, 29, 399-404.
27.     T. P. Cheung, C. Xue, K. S. -Y. Leung, K. Chan, C. G. Li, Aristolochic acids detected in some raw chinese medicinal herbs and manufactured herbal products - A consequence of inappropriate nomenclature and imprecise labelling, Clin. Toxicol., 2006, 44, 371-378.
26.     G. S. Qian, S. Y. Leung, G. H. Lu, K. S. -Y. Leung*, Differentiation of Rhizoma et Radix Polygoni Cuspidati from closely related herbs by HPLC fingerprinting, Chem Pharm. Bull., 2006, 54, 1179-1186.
25.     Y. N. Hu, Z. H. Jiang, K. S. -Y. Leung, Z. Z. Zhao, Simultaneous determination of naphthoquinone derivatives in Boraginaceous herbs by high-performance liquid chromatography, Anal. Chim. Acta, 2006, 577, 26-31.
24.     Z. T. Liang, Z.H. Jiang, K. S. -Y. Leung, Y. Peng, Z.Z. Zhao, Distinguishing the medicinal herb Oldenlandia diffusa from similar species of the same genus using fluorescence microscopy, Microsc Res Techniq, 2006, 69(4) , 277-282.
23.     K. S. -Y. Leung, Z. X. Bian, D. Moher, S. Dagenais, Y. P. Li, L. Liu, T. X. Wu, J. X. Mia, Improving the quality of randomized controlled trials in Chinese herbal medicine, Part III: quality control of Chinese herbal medicine used in randomized controlled trials (Invited Review), Chin. J. Integr. Med., 2006, 4, 225-232.
22.     L. S. Qin, H. Zhang, G. H. Lu, K. Chan, K. S. -Y. Leung, C. Chen, Determination of oleanolic acid in Caulis Clematidis Armandii by HPLC, West China Journal of Pharmaceutical Sciences, 2006, 21, 273-274.
21.     J. Meng, X. P. Dong, Z. H. Jiang, K. S. -Y. Leung, Z. Z. Zhao., Study on chemical constituents of flavonoids in fresh herb of Houttuynia cordata, China Journal of Chinese Materia Medica, 2006, 31, 1335-1337.
20.     K. S. -Y. Leung*, K. Chan, A. C. -K. Lau and G. H. Lu, Measurement uncertainty for total ash and acid-insoluble ash determination of Chinese materia medica, Accredit. Qual. Assur., 2005, 10, 289-294.
19.     K. S. -Y. Leung*, K. Chan and C. L. Chan, Systematic Evaluation of organochlorine pesticide residues in Chinese materia medica, Phytother. Res., 2005, 19, 514-518.
18.     T. Yi, K. S. -Y. Leung*, G. H. Lu, H. Zhang, K. Chan, Identification and comparative determination of senkyunolide a in traditional chinese medicinal plant Ligusticum chuanxiong and Angelicae sinensis by HPLC coupled with DAD and ESI-MS, Chem. Pharm. Bull., 2005, 53, 1480-1483.
17.     J. Meng, K. S. -Y. Leung, Z. H. Jiang, X. P. Dong, Z. Z. Zhao, Establishment of GC-MS fingerprint of fresh Houttuynia cordata, Chem. Pharm. Bull., 2005, 53, 1484-1489.
16.     J. Meng, K. S. -Y. Leung, Z. H. Jiang, X. P. Dong, Z. Z. Zhao, Establishment of HPLC-DAD-MS fingerprint of fresh Houttuynia cordata, Chem. Pharm. Bull., 2005, 53, 1604-1609.
15.     Z. Z. Zhao, J. Lu, K. S. -Y. Leung, C. L. Chan, Z. H. Jiang, Determination of Patchoulic Alcohol in Herba Pogostemonis by GC-MS-MS, Chem. Pharm. Bull., 2005, 53, 856-860.
14.     G. H. Lu, K. Chan, K. S. -Y. Leung, C. L. Chan, Z. Z. Zhao, Z. H. Jiang, Assay of free ferulic acid and total ferulic acid for quality assessment of Angelica sinensis, J. Chromatogr. A, 2005, 1068, 209-219.
13.     G. H. Lu, K. Chan, Y. Z. Liang, K. S. -Y. Leung, C. L. Chan, Z. H. Jiang Z. Z. Zhao, Development of high performance liquid chromatographic fingerprints for distinguishing Chinese angelica from related umbelliferae herbs, J. Chromatogr. A, 2005, 1073, 383-392.
12.     Y. Peng, C. Ma, Y. W. Li, K. S. -Y. Leung, Z. H. Jiang, Z. Z. Zhao, Quantification of zeaxanthin dipalmitate and total carotenoids in Lycium fruits (Fructus Lycii), Plant Foods Hum. Nutr., 2005, 60, 161-164.
11.     K. S. -Y. Leung*, K. Chan, Regulatory system of proprietary Chinese medicine in Hong Kong (Invited Review), Journal of Complementary and Integrative Medicine, 2004, 1(1), article 001.
10.     G. H. Lu, K. Chan, C. L. Chan, K. S. -Y. Leung, Z. H. Jiang, Z. Z. Zhao, Quantification of ligustilides in the roots of Angelica sinensis and related umbelliferous medicinal plants by high performance liquid chromatography and liquid chromatography-mass spectrometry, J. Chromatogr. A, 2004, 1046, 101-107.
9.       W. Y. Wong, S. H. Cheung, S. M. Lee, K. S. -Y. Leung, Synthesis, characterization and crystal structures of some tungsten and triosmium carbonyl complexes with monopyridyl and dipyridyl azo ligands, J Organomet Chem., 2000, 596, 36-45
8.       K. S. -Y. Leung and W. -T. Wong, Synthesis, structural characterisation and reactivities of hexaosmium carbonyl clusters with six membered cyclic thioether and thioxane ligands, J. Chem. Soc., Dalton Trans., 1999, 2077-2086
7.       K. S. -Y. Leung and W. -T. Wong, Formation of hexaosmium raft clusters from [Os6(CO)16(MeCN)2]: Synthesis, structural characterization and reactivities of [Os6(CO)1632-C5H4NS)2] and [Os6(CO)17(μ-H)(μ42-C5H4NS)], J. Chem. Soc., Dalton Trans., 1999, 2521-2524
6.       K. S. -Y. Leung and W. -T. Wong, Synthesis, structural characterization, electrochemistry and reactivities of heptaosmium carbonyl clusters bearing thioxane ligands: crystal and molecular structures of [Os7(CO)16{μ-S(CH2)2OCH2CH2}2], [Os7(CO)17{μ-S(CH2)2OCH2CH2}{S(CH2)2OCH2CH2}] and [Os7(CO)18{μ-S(CH2)2OCH2CH2}], Eur. J. of Inorg. Chem., 1999, 1757-1763
5.       K. S. -Y. Leung, Synthesis, structural characterisation and electrochemistry of a heptaosmium carbonyl cluster bearing dppf moiety: crystal and molecular structure of [Os7(CO)1742-CO)(μ-NCMe)(μ-dppf)], Inorg. Chem. Commun, 1999, 498-502
4.       K. S. -Y. Leung and Y. Li, Synthesis and characterisation of tetraosmium carbonyl clusters bearing an azo type ligand: crystal and molecular structures of [Os4(μ-H)4(CO)10(MeCN)(NC5H4N=NPh)], Inorg. Chem. Commun, 1999, 599-603
3.       Z. Li, J. Huang, Y. Qian, Albert S. C. Chan, K. S. -Y. Leung and W. -T. Wong, A novel route to titanium compounds containing cyclopentadienyl ligands with bromoethyl substituents; molecular structure of [η5-C5H4CH2CH2Br)TiBr(μ-O)]4, Inorg. Chem. Commun, 1999, 9(2), 396-398
2.       K. S. -Y. Leung and W. -T. Wong, Coupling reaction of alkylnitriles (RCN, R=Me, Et) with 7-azaindole on a hexaosmium carbonyl cluster core; molecular structure of [Os6(CO)14(μ-CO)(m-H)(μ-η1: η2- C9H8N3)], J. Chem. Soc., Dalton Trans., 1998, 1939-1940
1.       K. S. -Y. Leung and W. -T. Wong, Synthesis and characterization of hexaosmium carbonyl clusters containing pyridine ligands: crystal and Molecular Structures of [Os6(CO)1542-CO)(C5H5N)3], [Os6(CO)15(μ-H)(μ-CO)(μ3-O)(C5H5N)(μ-η2-NC5H4)] and [Os6(CO)14(μ-H)(μ-CO)(CH3CN)(C5H5N)(μ-η2-NC5H4)], J. Chem. Soc., Dalton Trans., 1997, 4357-4360