Educational Background

  • B.Sc., The University of Hong Kong
  • M.Phil., The Chinese University of Hong Kong
  • Ph.D., Hong Kong University of Science and Technology

Current Research Interests

  • Functional spatial proteomics workflow development and application.
  • Protein posttranslational modification analysis.
  • Pathological process of metabolic osteoarthritis and musculoskeletal diseases.

Selected Publications

  1. Lin Zhu#,*, Xin Diao#, Chenrui Yuan#, Chun Man Lawrence Lau, Jianing Wang, Wenlong Wu, Ali Mobasheri, Xavier Houard, Chunyi Wen*, Zongwei Cai*. Integrative Spatially Resolved Proteomic and Metabolomic Imaging Reveals Synovitis Endotypes Implicated in Osteoarthritis Progression. Theranostics, 2025; 15(18):9729-9741.
  2. Lin Zhu, Chun Man Lawrence Lau, Chunyi Wen. Development of Mass Spectrometry-Based Integrative Spatial MultiOmics Approach for Metabolic Synovitis Endotyping in Osteoarthritis. Osteoarthritis and Cartilage, 2026, 34, S75-S76.
  3. Ling Yan, Jiacheng Fang, Huimin Zhang, Yali Lin, Dan Li, Yingyan Zhou, Lin Zhu*, Zhi Zhu*, Pengyuan Yang, Zongwei Cai*. Temperature-Responsive Agarose-Based Digital Microfluidics: An In-Chip Sample Preparation To Mass Spectrometry Analysis for Trace Cells and Single-Cell Proteomics. Analytical Chemistry, 2026, 98, 3, 2285–2296.
  4. Qianya Wan#, Lin Zhu#, Cien Chen#, Li Zhong, Houying Leung, Wei Li, Chang Xu, Xi Yao, Huan Hu, Mandi Wu, Yuxin Hou, Yiran Wang, Sheng Chen, Mingyu Pan*, Zongwei Cai*, Ming-liang He*. PIM1 Attenuates Innate Immunity to Foster Coronavirus Replication through Ubiquitin Ligase b-TrCP Mediated IFNAR1 Degradation. Advanced Science, 2025, 12(37): e03487.
  5. Rui Shi#, Yanyan Chen#, Wenlong Wu#, Xin Diao, Leijian Chen, Xingxing Liu, Haijiang Wu, Jianing Wang, Lin Zhu*, Zongwei Cai*. Mass Spectrometry-Based Spatial Multiomics Revealed Bioaccumulation Preference and Region-Specific Responses of PFOS in Mice Cardiac Tissue. Environmental Science & Technology, 2025, 59, 4, 1957–1968.
  6. Wanlin Guo, Yanhao Zhang, Yawei Wang, Lin Zhu,* Zongwei Cai.* A comprehensive, simple, robust, and solvent-free method covering ultrashort- to long-chain PFAS in atmospheric samples. Analytical Chemistry, 2025, 97, 27, 14838–14846. DOI: 10.1021/acs.analchem.5c03123.
  7. Yuqi Zhang,# Karen Ching,# Lanlan Zhang,#, Lin Zhu,# Siu Ling Yip, Xuan Lu, Zhongyu Liu, Zongwei Cai, Man Ting Au, Chunyi Wen. Endothelial Dysfunction Contributes to Chondrocyte Senescence Associated With Insulin-Like Growth Factor-Binding Protein-6 in a Spontaneously Hypertensive Rat Model. Journal of the American Heart Association, 2025, e042132.
  8. Yingyan Zhou, Cun Li, Yanyan Chen, Yifei Yu, Xin Diao, Raymond Chiu, Jiacheng Fang, Yuting Shen, Jianing Wang, Lin Zhu,* Jie Zhou,* Zongwei Cai.* Human Airway Organoids and Multimodal Imaging-based Toxicity Evaluation of 1-Nitropyrene. Environmental Science & Technology, 2024, 58, 14, 6083–92.
  9. Guangshan Xie#, Lin Zhu#,* Siwen Liu#, Cun Li, Xin Diao, Yanhao Zhang, Xiuli Su, Yingyan Zhou, Yuanyuan Song, Guodong Cao, Li Zhong, Pui Wang, Xiaojuan Liu, Bobo Mok, Shusheng Zhang, Dong-Yan Jin, Jie Zhou, Honglin Chen, Zongwei Cai*. Multi-omics analysis of attenuated variant reveals potential evaluation marker of host damaging for SARS-CoV-2 variants. SCIENCE CHINA Life Sciences, 2024, 67(1): 83-95.
  10. Man Ting Au, Junguo Ni, Kaiming Tang, Wei Wang, Lanlan Zhang, Hantang Wang, Fangyi Zhao, Zhan Li, Peng Luo, Lawrence Chun-Man Lau, Ping-Keung Chan, Cuiting Luo, Bo Zhou, Lin Zhu, Charlie Yuli Zhang, Tianshu Jiang, Marianne Lauwers, Jasper Fuk-Woo Chan, Shuofeng Yuan, Chunyi Wen. Blockade of endothelin receptors mitigates SARS-CoV-2-induced osteoarthritis. Nature Microbiology, 2024, 9, 2538–2552.
  11. Shiyan Wang,# Shanshan Gao,# Yong Zeng#, Lin Zhu, YYulin Mo, Chichun Wong, Yi Bao, Peiran Su, Jianning Zhai, Lina Wang, Fraser Soares, Xin Xu, Huarong Chen, Kebria Hezaveh, Xinpei Ci, Aobo He, Tracy McGaha, Catherine O’Brien, Robert Rottapel, Wei Kang, Jianfeng Wu, Gang Zheng, Zongwei Cai, Jun Yu, Housheng Hansen He*. N6-methyladenosine reader YTHDF1 promotes ARHGEF2 translation and RhoA signaling in colorectal cancer. Gastroenterology, 2021, 162(4).
  12. Man Lung Yeung, Jade Lee Lee Teng, Lilong Jia, Chaoyu Zhang, Chengxi Huang, Jian-Piao Cai, Runhong Zhou, Kwok-Hung Chan, Hanjun Zhao, Lin Zhu, Kam-Leung Siu, Sin-Yee Fung, Susan Yung, Tak Mao Chan, Kelvin Kai-Wang To, Jasper Fuk-Woo Chan, Zongwei Cai, Susanna Kar Pui Lau, Zhiwei Chen, Dong-Yan Jin, Patrick Chiu Yat Woo, Kwok-Yung Yuen. Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system. Cell, 2021, 184 (8), 2212-2228. E12.