Educational Background

  • MA, DPhil, Oxford University (1974-1980)
  • Postdoctoral: NATO Fellow, Strasbourg, France (1980/81)

Current Research Interests

  • Functional probes for imaging and sensing, using luminescence, EPR, MRS and MRI ; coordination complexes and conjugates; chiral probes and targeting.

Career and Research Profile

David Parker spent over fifty years living in the North-East of England. Born in County Durham, he graduated with a First Class degree in Chemistry from Oxford University in 1978. He gained a D.Phil. in 1980, working with John M Brown FRS in the Dyson Perrins Laboratory on the mechanism of asymmetric catalysis using organo-rhodium complexes. In late 1980, he took up a NATO Fellowship to study with Jean-Marie Lehn in Strasbourg, returning to Durham in January 1982 to a Lectureship in Chemistry, with promotion to a Chair in 1992. He enjoyed a 40-year academic career at Durham, serving as the Chairman of Durham Chemistry on two occasions, and was on the UK RAE Panel in 2008. Today, 36 of his former PhDs and post-doctoral assistants hold leading academic positions around the world. He was elected FRS in 2002, aged 45.
His research has ranged widely over the design, synthesis and mode of action of targeted probes and sensors using luminescence and magnetic resonance. In addition he has studied both d and f block metal coordination chemistry, as well as some key contributions to chiral NMR analysis. In particular, he developed families of metal complexes and bioconjugates that bind reversibly or react selectively, examining their behaviour in vitro and in cellulo, prior to in vivo applications. He holds over 25 licensed patents and has published over 400 articles, (h = 86).
https://en.wikipedia.org/wiki/David_Parker_(chemist)

Selected Publications

  1. D. F. De Rosa, M Starck, D. Parker and R. Pal, “Unlocking same-sign CPL: assessing solvent polarity and racemisation kinetics in nine-coordinate europium (III) complexes”, Chem. Eur. J. , 2024, 30, e202303227; doi.org/10.1002/chem.202303227.
  2. T.L. Cheung, Z. Ju, W. Zhang, D. Parker and R. Deng, “Mechanistic Investigation of Sensitised Europium Luminescence: Excited State Dynamics and Luminescence Lifetime Thermometry”, ACS Appl. Mater. Interfaces , 2024, 16, 43933-43941; doi.org/10.1021/acsami.4c06899
  3. X. Wen, H. Li, Z. Ju, R. Deng and D. Parker, “Mechanism of Action and Evaluation of Ratiometric Probes for Uric Acid Using Lanthanide Complexes with Tetraazatriphenylene Sensitisers”, Chem. Sci. , 2024, in press; DOI: 10.1039/D4SC05743K
  4. S. Maity, B. D. Price, C. B. Wilson, A. Mukherjee, M. Starck, M. Z. Wilson, J. E. Lovett, S. Han, D Parker and M. S Sherwin, “Triggered functional dynamics of AsLOV2 by time-resolved paramagnetic resonance at high magnetic fields”, Angew. Chem. Int. Ed. , 2023, 62, e202212832; DOI: 10.1101/2022.10.12.511365
  5. Huishan Li, Jing-Xiang Zhang, Hongguang Li and David Parker, “Spectral imaging in microscopy aids evaluation of the luminescent probe behaviour of europium complexes”, J. Luminesc. , 2023, 260, 119852; doi.org/10.1016/j.jlumin.2023.119852
  6. P. Stachelek, L. Mackenzie, D. Parker and R. Pal., “Circularly polarised luminescence laser scanning confocal microscopy to study live cell chiral molecular interactions”, Nature Communications, 2022, 13, 553-560, DOI : 10.1038/s41467-022-28220-z.
  7. Jack D. Fradgley, Martina Delbianco, Matthieu Starck, James W. Walton, Jurriaan M. Zwier and David Parker, “Comparative analysis of lanthanide excited state quenching by electronic energy and electron transfer processes”, Faraday Discuss, 2022, 234, 159-174 DOI: 10.1039/D1FD00059D .
  8. Jack D Fradgley, Ka-Leung Wong and David Parker, “The Design of Luminescent Lanthanide Probes and Sensors”, Chem. Soc. Rev., 2021, 50, 8193-8213, DOI: 10.1039/d1cs00310k.
  9. Matthieu Starck, Jack D. Fradgley, Davide F. De Rosa, Andrei S. Batsanov, Maria Papa, Michael J. Taylor, Janet E. Lovett, Jacob C. Lutter, Matthew J. Allen and David Parker, “Versatile para-substituted pyridine lanthanide coordination complexes allow late stage tailoring of complex function”, Chem. Eur. J., 2021, 27, 17921-17927. https://doi.org/10.1002/chem.202103243
  10. E. A. Suturina, I. Kuprov, N. F. Chilton and D. Parker, “How the Ligand Field in Lanthanide Coordination Complexes Determines Magnetic Susceptibility Anisotropy, Paramagnetic NMR Shift and Relaxation”, Acc. Chem. Res., 2020, 53(8), 1520-1534, DOI 10.1201/acs/accounts.0c00275.