Educational Background

  • B.Sc., Indiana University of Pennsylvania
  • Ph.D., University of Minnesota
  • Postdoctoral: Medicinal Chemistry Division, Pharmacia Corporation

Current Research Interests

  • Natural Product Synthesis, Organic Methodology, Catalysis, Medicinal Chemistry, Chemical Biology and Molecular Imaging.

Selected Publications

  1. L. Zhu, W. Ma, M. Zhang, M. M.-L. Lee, W.-Y. Wong, B. D. Chan, Q. Yang, W.-T. Wong, W. C.-S. Tai, C.-S. Lee, “Scalable Synthesis Enabling Multilevel Bio-Evaluations of Natural Products for Discovery of Lead Compounds”, Nat.Commun., 9, 1283 (2018).
  2. Q. Yang, W. Ma, G. Wang, W. Bao, X. Dong, X. Laing, L. Zhu, C.-S. Lee, “Tunable Cyclization Strategy for the Synthesis of Zizaene-, allo-Cedrane-, seco-Kaurane-, and seco-Atesane-Type Skeletons”, Org. Lett., 19, 5324 (2017).
  3. T.-H. Tsoi, Y.-J. Gu, W.-S. Lo, W.-T. Wong, W.-T. Wong, C.-F. Ng, C.-S. Lee, K.-L. Wong, “Study on the aggregation of DNA capped gold nanoparticles: a smart and flexible aptasensor for spermine sensing”, ChemPlusChem , 82, 802 (2017).
  4. G. Du, G. Wang, W. Ma, Q. Yang, W. Bao, X. Liang, L. Zhu, C.-S. Lee, “Syntheses of Diverse Natural Products via Dual-mode Lewis Acid Induced Cascade Cyclization Reactions”, Synlett, 28, 1394 (2017).
  5. X. Liang, L. Zhou, L. Min, W. Ye, W. Bao, W. Ma, Q. Yang, F. Qiao, X. Zhang, C.-S. Lee, “Diastereoselective Total Synthesis of (±)-Basiliolide B and (±)-epi-8-Basiliolide B”, J. Org. Chem., 82, 3463 (2017).
  6. Z. Liang, T.-H. Tsoi, C.-F. Chan, L. Dai, Y. Wu, G. Du, L. Zhu, C.-S. Lee, W.-T. Wong, G.-L. Law, K.-L. Wong, “A smart “off–on” gate for the in situ detection of hydrogen sulphide with Cu(II)-assisted europium emission”, Chem. Sci., 7, 2151 (2016).
  7. G. Du, W. Bao, J. Huang, S. Huang, H. Yue, W. Yang, L. Zhu, Z. Liang, C.-S. Lee, “Enantioselective Synthesis of the ABC-Tricyclic Core of Phomactin A by a γ-Hydroxylation Strategy”, Org. Lett., 17, 2062 (2015).
  8. W. Yang, J. Cao, M. Zhang, R. Lan, L. Zhu, G. Du, S. He, C.-S. Lee, “Systemic Study on the Biogenic Pathways of Yezo’otogirins: Total Synthesis and Antitumor Activities of (±)-Yezo’otogirin C and Its Structural Analogues”, J. Org. Chem., 80, 836 (2015).
  9. L. Min, Y. Zhang, X. Liang, J. Huang, W. Bao, C.-S. Lee, “A Biomimetic Synthesis of (±)-Basiliolide B”, Angew. Chem. Int. Ed., 53, 11294 (2014).
  10. S. He, W. Yang, L. Zhu, G. Du, C.-S. Lee, “Bioinspired Total Synthesis of (±)-Yezo’otogirin C”, Org. Lett., 16, 496 (2014). (Highlighted by E. M. Carreira in Synfacts)
  11. L. Zhu, C. Zhou, W. Yang, S. He, G.-J. Cheng, X. Zhang, C.-S. Lee, “Formal Syntheses of (±)-Platensimycin and (±)-Platencin via a Dual-Mode Lewis Acid Induced Cascade Cyclization Approach”, J. Org. Chem., 78, 7912 (2013).
  12. L. Zhu, Y. Han, G. Du, C.-S. Lee, “A Bifunctional Lewis Acid Induced Cascade Cyclization to the Tricyclic Core of ent-Kaurenoids and Its Application to the Formal Synthesis of (±)-Platensimycin”, Org. Lett., 15, 524 (2013).