Educational Background

  • MChem, University of Oxford, UK
  • DPhil, University of Oxford, UK

Current Research Interests

  • Computational chemistry; protein chemistry; drug discovery; NMR; chemical education.

Selected Publications

  1. Chan, H. T. H.; Brewitz, L.; Lukacik, P.; Strain-Damerell, C.; Walsh, M. A.; Schofield, C. J.; Duarte, F. Studies on the selectivity of the SARS-CoV-2 papain-like protease reveal the importance of the P2′ proline of the viral polyprotein. RSC Chem. Biol. 2024, 5, 117.
  2. Brewitz, L.; Chan, H. T. H.; Lukacik, P.; Strain-Damerell, C.; Walsh, M. A.; Duarte, F.; Schofield, C. J. Mass spectrometric assays monitoring the deubiquitinase activity of the SARS-CoV-2 papain-like protease inform on the basis of substrate selectivity and have utility for substrate identification. Bioorg. Med. Chem. 2023, 95, 117498.
  3. Chan, H. T. H.; Oliveira, A. S. F.; Schofield, C. J.; Mulholland, A. J.; Duarte, F. Dynamical Nonequilibrium Molecular Dynamics Simulations Identify Allosteric Sites and Positions Associated with Drug Resistance in the SARS-CoV-2 Main Protease. JACS Au 2023, 3, 1767.
  4. Chan, H. T. H.#; Moesser, M. A.#; Walters, R. K.#; Malla, T. R.#; Twidale, R. M.; John, T.; Deeks, H. M.; Johnston-Wood, T.; Mikhailov, V.; Sessions, R. B.; Dawson, W.; Salah, E.; Lukacik, P.; Strain-Damerell, C.; Owen, C. D.; Nakajima, T.; Świderek, K.; Lodola, A.; Moliner, V.; Glowacki, D. R.; Spencer, J.; Walsh, M. A.; Schofield, C. J.; Genovese, L.; Shoemark, D. K.; Mulholland, A. J.; Duarte, F.; Morris, G. M. Discovery of SARS-CoV-2 Mpro peptide inhibitors from modelling substrate and ligand binding. Chem. Sci. 2021, 12, 13686. (#contributed equally)
  5. Malla, T. R.; Tumber, A.; John, T.; Brewitz, L.; Strain-Damerell, C.; Owen, C. D.; Lukacik, P.; Chan, H. T. H.; Maheswaran, P.; Salah, E.; Duarte, F.; Yang, H.; Rao, Z.; Walsh, M. A.; Schofield, C. J. Mass spectrometry reveals potential of β-lactams as SARS-CoV-2 Mpro inhibitors. Chem. Commun. 2021, 57, 1430.
  6. Aertker, K. M. J.; Chan, H. T. H.; Lohans, C. T.; Schofield, C. J. Analysis of β-lactone formation by clinically observed carbapenemases informs on a novel antibiotic resistance mechanism. J. Biol. Chem. 2020, 295, 16604.
  7. Lohans, C. T.#; Chan, H. T. H.#; Malla, T. R.; Kumar, K.; Kamps, J. J. A. G.; McArdle, D. J. B.; van Groesen, E.; de Munnik, M.; Tooke, C. L.; Spencer, J.; Paton, R. S.; Brem, J.; Schofield, C. J. Non-Hydrolytic β-Lactam Antibiotic Fragmentation by L,D-Transpeptidases and Serine β-Lactamase Cysteine Variants. Angew. Chem. Int. Ed. 2019, 58, 1990. (#contributed equally)