Teaching Staff
 
CHENG, Yuen-Kit - Associate Professor, Student Exchange Coordinator
鄭元傑博士

Educational Background
  • B.Sc. (Hons.), The Chinese University of Hong Kong
  • Ph.D., Houston, USA

Professional Appointments
  • Postdoctorate and Research Associate, University of Texas (Austin)

Current Research Interests
  • Biomolecular modeling and QSPR. 

Contacts

Selected Publications
  1. P. Zhao, S.-K. Chen, Y.-H. Cai, X. Lu, Z. Li, Y.-K. Cheng, C. Zhang, X. Hu, X. He, H.-B. Luo, “The Molecular Basis for the Inhibition of PDE-4D by Three Natural Resveratrol Analogs”, Biochim. Biophys. Acta., 1834, 2089-2096 (2013).
  2. Z. Li, Y.-H. Cai, Y.-K. Cheng, X. Lu, Y.-X. Shao, X. Li, M. Liu, P. Liu, H.-B. Luo, “Identification of Novel PDE-4D Inhibitors Prescreened by MD-augmented Modeling and Validated by Bioassay”, J. Chem. Info. Model., 53, 972-981 (2013).
  3. J. K. C. Lau, Y. K. Cheng, “An Update View on the Substrate Recognition Mechanism of Phosphodiesterases: A computational study of PDE10 and PDE4 bound with cyclic nucleotides”, Biopolymers, 97, 910-922 (2012).
  4. H. H. Kwok, G. L. Guo, J. K. C. Lau, Y. K. Cheng, J. R. Wang, Z. H. Jiang, M. H. Keung, N. K. Mak, P. Y. K. Yue, R. N. S. Wong, “Stereoisomers Ginsenosides-20(S)-Rg3 and -20(R)-Rg3 Differentially Induce Angiogenesis through PPARg”, Biochem. Pharmacol., 83, 893-902 (2012).
  5. M. Liu, M. Yuan, Z. Li, Y. K. Cheng, H. B. Luo, X. Hu, “Structural Investigation into the Inhibitory Mechanisms of Indomethacin and its Analogues towards Human Glyoxalase I”, Bioorg. & Med. Chem. Lett., 21, 4243-4247 (2011).
  6. J. K. C. Lau, X. B. Li and Y. K. Cheng, “A Substrate Selectivity and Inhibitor Design Lesson from the PDE10-cAMP Crystal Structure”, J. Phys. Chem. B, 114, 5154-5160 (2010).
  7. S. H. Yang, Y. K. Cheng and S. L. Yuan, “Mesoscale Simulation on Patterned Nanotube Model for Amphiphilic Block Copolymer”, J. Mol. Modeling, 16, 1819-1824 (2010).
  8. H. B. Luo, C. Zheng and Y. K. Cheng, “Is Phosphatidylcholine-Saturated Alkyl Column a Convenient Replacement for Immobilized-Artificial-Membrane?”, J. Chromatgr. A, 1176, 100-106 (2007).
  9. W. K. Lo, W. K. Wong, W. Y. Wong, J. Guo, K. T. Yeung, Y. K. Cheng, X. Yang and R. A. Jones, “Heterobimetallic Zn(II)-Ln(III) Phenylene-bridged Schiff Base Complexes: Computational Studies and Evidences for Singlet Energy Transfer as the Main Pathway in the Sensitization of Near-infrared Nd3+ Luminescence”, Inorg. Chem., 45, 9315-9325 (2006).
  10. J. K. C. Lau and Y. K. Cheng, “SER-HIS-ASP Catalytic Triad in Model Non-aqueous Solvent Environment. A Computational Study”, Bioorg. & Med. Chem. Lett., 16, 5797-5800 (2006).
  11. Y. K. Cheng and P. J. Rossky, “Surface Topography Dependence of Biomolecular Hydrophobic Hydration”, Nature, 392, 696-699 (1998).
  12. Y. K. Cheng and B. M. Pettitt, “Stabilities of Double- and Triple-Strand Helical Nucleic Acids”, Prog. Biophys. Mol. Biol., 58, 225-257 (1992).