Teaching Staff
 
KWONG, Daniel W. J. - Associate Professor, Associate Dean of Science
鄺維正博士

Educational Background
  • M.Sc., Yale, USA
  • Ph.D. (Chem. Eng.), Yale, USA
  • Ph.D. (Chem), Baylor, USA
  • Postdoctoral: U.S. A. Dept. of Energy Ames Research Laboratory, Iowa State University

Current Research Interests

Bioinorganic photochemistry; development of novel porphyrins, phthalocyanines and their conjugates as tumor-imaging and photodynamic therapeutic agents; mechanistic studies of DNA photo-oxidation mediated by vanadium(V)-peroxo complexes.

Contacts

Selected Publications
  1. Y. Zhou, C. F. Chan, D. W. J. Kwong, G. L. Law, S. Cobb, W. K. Wong, K. L. Wong, " αvβ3-Isoform specific erbium complexes highly specific for bladder cancer imaging and photodynamic therapy", Chem. Comm., 53, 557-560 (2017).
  2. W. Wang, Z. Mao, M. Wang, L. J. Liu, D. W. J. Kwong, C. H. Leung, D. L. Ma, “A Long Lifetime Iridium(III) Complex Chemosensor for the Selective Switch-On Detection of Al3+ Ions”, Chem. Comm., 52, 3611-3614 (2016).
  3. D. Qi, Q. Wang, H. Li, T. Zhang, R. Lan, D. W. J. Kwong, W. K. Wong, K. L. Wong, S. Li, F. Lu, “SILAC-based Quantitative Proteomics Identified Lysosome as a Fast Response Target to PDT Agent Gd-N Induced Oxidative Stress in Human Ovarian Cancer IGROV1 Cells”, Mol. BioSyst., 11, 3059-3067 (2015).
  4. T. Zhang, R. Lan, L. Gong, B. Wu, Y. Wang, D. W. J. Kwong, W. K. Wong, K. L. Wong, D. Xing, “An Amphiphilic BODIPY-Porphyrin Conjugate: Intense Two-Photon Absorption and Rapid Cellular Uptake for Two-Photon-Induced Imaging and Photodynamic Therapy”, ChemBioChem, 16, 2357-2364 (2015).
  5. H. Li, R. Lan, C. F. Chan, L. Jiang, L. Dai, D. W. J. Kwong, M. H. W. Lam, K. L. Wong, “Real-time In-situ Monitoring via Europium Emission of the Photo-release of Antitumor Cisplatin from a Eu-Pt Complex”, Chem. Comm., 51, 14022-14025 (2015).
  6. S. L. Ho, C. Y. Poon, C. Lin, T. Yan, D. W. J. Kwong, K. K. L. Yung, M. S. Wong, Z. Bian, H. W. Li, “Inhibition of b-Amyloid Aggregation by Albiflorin, Aloeemodin and Neohesperidin and their Neuroprotective Effect on Primary Hippocampal Cells against b-Amyloid Induced Toxicity”, Curr. Alzheimer Research, 12, 424-433 (2015).
  7. C. H. Leung, L. J. Liu, L. Lu, B. He, D. W. J. Kwong, C. Y. Wong, D. L. Ma, “A Metal-Based Tumour Necrosis Factor-a Converting Enzyme Inhibitor”, Chem. Comm., 51, 3973-3976 (2015).
  8. M. Wong, K. H. Leung, S. Lin, D. S. H. Chan, D. W. J. Kwong, C. H. Leung, D. L. Ma, “A Colorimetric Chemosensor for Cu2+ Ion Detection based on an Iridium(III) Complex”, Scientific Reports, 4, 4794 (2014).
  9. L. Lu, D. S. H. Chan, D. W. J. Kwong, H. Z. He, C. H. Leung, D. L. Ma, “Detection of Nicking Endonuclease Activity using a G-quadruplex-selective Luminescent Switch-On Probe”, Chemical Science, 5, 4561-4568 (2014).
  10. H. Ke, W. Ma, H. Wang, G. Cheng, H. Yuan, W. K. Wong, D. W.J. Kwong, H. L. Tam, K. W. Cheah, C. F. Chan and K. L. Wong, “Synthesis, Singlet-Oxygen Photogeneration, Two-Photon Absorption, Photo-Induced DNA Cleavage and Cytotoxic Properties of an Amphiphilic b-Schiff-Base Linked Ru(II) Polypyridyl-Porphyrin Conjugate”, J. Luminescence, 154, 356-361 (2014).
  11. J. X. Zhang, J. W. Zhou, C. F. Chan, T. C. K. Lau, D. W. J. Kwong, H. L. Tam, N. K. Mak, K. L. Wong, W. K. Wong, "Comparative Studies of the Cellular Uptake, Subcellular Localization, and Cytotoxic and Phototoxic Antitumor Properties of Ruthenium(II)-Porphyrin Conjugates with Different Linkers", Bioconjugate Chemistry, 23, 1623-1638 (2012).
  12. Z. Zhao, P. S. Chan, H. Li, K. L. Wong, R. N. S. Wong, N. K. Mak, J. Zhang, H. L. Tam, W. Y. Wong, D. W. J. Kwong, W. K. Wong, "Highly Selective Mitochondria-Targeting Amphiphilic Silicon(IV) Phthalocyanines with Axially Ligated Rhodamine B for Photodynamic Therapy", Inorg. Chem., 51, 812-821 (2012).