Teaching Staff
 
CHENG, Yuen-Kit - Associate Professor
鄭元傑博士

Educational Background
  • B.Sc. (Hons.), The Chinese University of Hong Kong
  • Ph.D., Houston, USA

Professional Appointments
  • Postdoctorate and Research Associate, University of Texas (Austin)

Current Research Interests
  • Biomolecular modeling;
  • Protein-ligand interactions of biological interests.

Contacts

Selected Publications
  1. J.K.-C. Lau, Y.-K. Cheng, “An Update View on the Substrate Recognition Mechanism of Phosphodiesterases: A computational study of PDE10 and PDE4 bound with cyclic nucleotides”, Biopolymers, 97(11), 910-922 (2012).
  2. H.-H. Kwok, G.-L. Guo, J. K.-C. Lau, Y.-K. Cheng, J.-R. Wang, Z.-H. Jiang, M.-H. Keung, N.-K. Mak, P.Y.-K. Yue, R.N.-S. Wong, "Stereoisomers Ginsenosides-20(S)-Rg3 and -20(R)-Rg3 Differentially Induce Angiogenesis through PPARg", Biochem. Pharmacol., 83, 893-902 (2012).
  3. M. Liu, M. Yuan, Z. Li, Y.-K. Cheng, H.-B. Luo, X. Hu, "Structural Investigation into the Inhibitory Mechanisms of Indomethacin and its Analogues towards Human Glyoxalase I", Bioorg. & Med. Chem. Lett., 21, 4243-4247 (2011).
  4. J.K.-C Lau, X.-B. Li and Y.-K. Cheng, "A Substrate Selectivity and Inhibitor Design Lesson from the PDE10-cAMP Crystal Structure", J. Phys. Chem. B, 114, 5154-5160 (2010).
  5. S.-H. Yang, Y.-K. Cheng and S.-L. Yuan, "Mesoscale Simulation on Patterned Nanotube Model for Amphiphilic Block Copolymer", J. Mol. Modeling, 16, 1819-1824 (2010).
  6. Y.-M. Lee, C.-M. Ting, Y.-K. Cheng, T.-P. Fan, R. N.-S. Wong, M. L. Lung and N.-K. Mak, "Mechanism of 2-Methoxyestradiol-induced Apoptosis and G2/M Cell-cycle Arrest of Nasopharyngeal Carcinoma Cells", Cancer Lett., 268, 295-307 (2008).
  7. H.-B. Luo, C. Zheng and Y.-K. Cheng, "Is Phosphatidylcholine-Saturated Alkyl Column a Convenient Replacement for Immobilized-Artificial-Membrane?", J. Chromatgr. A, 1176, 100-106 (2007).
  8. X. Leng, C.-F. Choi, H. Luo, Y.-K. Cheng and K. P. Ng, "Host-Guest Interactions of 4-carboxyphenoxy Phthalocyanines and b-cyclodextrin in Aqueous Media", Org. Lett., 9, 2497-2500 (2007).
  9. W.-K. Lo, W.-K. Wong, W.-Y. Wong, J. Guo, K.-T. Yeung, Y.-K. Cheng, X. Yang and R.A. Jones, "Heterobimetallic Zn(II)-Ln(III) Phenylene-bridged Schiff Base Complexes: Computational Studies and Evidences for Singlet Energy Transfer as the Main Pathway in the Sensitization of Near-infrared Nd3+ Luminescence", Inorg. Chem., 45, 9315-9325 (2006).
  10. J.K.-C. Lau and Y.-K. Cheng, "SER-HIS-ASP Catalytic Triad in Model Non-aqueous Solvent Environment. A Computational Study", Bioorg. & Med. Chem. Lett., 16, 5797-5800 (2006).
  11. Y.-K. Cheng and P.J. Rossky, "Surface Topography Dependence of Biomolecular Hydrophobic Hydration", Nature, 392, 696-699 (1998).
  12. Y.-K. Cheng and B.M. Pettitt, "Stabilities of Double- and Triple-Strand Helical Nucleic Acids", Prog. Biophys. Mol. Biol., 58, 225-257 (1992).